UVRAG

UVRAG
Identifiers
Aliases	UVRAG, DHTX, VPS38, p63, UV radiation resistance associated
External IDs	OMIM: 602493 MGI: 1925860 HomoloGene: 31150 GeneCards: UVRAG
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.5 Start 75,815,210 bp End 76,144,232 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E1 Start 98,534,228 bp End 98,790,348 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Achilles tendon subcutaneous adipose tissue abdominal fat monocyte parietal pleura lymph node thymus sural nerve tibia Top expressed in calvaria spleen secondary oocyte thymus spermatocyte subcutaneous adipose tissue right lung blood liver ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein binding SNARE binding Cellular component cytoplasm HOPS complex endosome late endosome centrosome chromosome midbody early endosome phagocytic vesicle endoplasmic reticulum DNA-dependent protein kinase complex lysosome chromosome, centromeric region protein-containing complex autophagosome membrane autophagosome cytoplasmic vesicle Biological process double-strand break repair via classical nonhomologous end joining regulation of cytokinesis regulation of protein serine/threonine kinase activity retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum multivesicular body sorting pathway chromosome segregation regulation of vesicle-mediated transport receptor catabolic process cellular response to DNA damage stimulus autophagy spindle organization viral entry into host cell maintenance of Golgi location DNA repair SNARE complex assembly positive regulation of autophagosome maturation centrosome cycle autophagosome maturation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7405 78610 Ensembl ENSG00000198382 ENSMUSG00000035354 UniProt Q9P2Y5 Q8K245 RefSeq (mRNA) NM_003369 NM_178635 RefSeq (protein) NP_003360 NP_848750 Location (UCSC) Chr 11: 75.82 – 76.14 Mb Chr 7: 98.53 – 98.79 Mb PubMed search
Wikidata
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UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.

Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.