Growth-hormone-releasing hormone receptor

GHRHR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XDG
Identifiers
Aliases	GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
External IDs	OMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR
Gene location (Human)
Chr.	Chromosome 7 (human)
End	30,993,254 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	55,365,515 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; oocyte; ; secondary oocyte; ; hypothalamus; ; cingulate gyrus; ; amygdala; ; nucleus accumbens; ; caudate nucleus; ; ascending aorta;
	Top expressed in
	pituitary gland; ; anterior pituitary; ; entorhinal cortex; ; soleus muscle; ; proximal tubule; ; yolk sac; ; tibialis anterior muscle; ; medulla oblongata; ; inferior colliculus; ; primary motor cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; growth factor binding; signal transducer activity; peptide hormone binding; protein binding; growth hormone-releasing hormone receptor activity; transmembrane signaling receptor activity; G protein-coupled peptide receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; nuclear matrix; plasma membrane; secretory granule; cell surface; nuclear inner membrane; sarcolemma; nuclear outer membrane;
Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway; determination of adult lifespan; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; response to glucocorticoid; cell maturation; adenohypophysis development; water homeostasis; activation of adenylate cyclase activity; response to estrogen; mammary gland development; response to insulin; positive regulation of circadian sleep/wake cycle, non-REM sleep; cell surface receptor signaling pathway; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of insulin-like growth factor receptor signaling pathway; growth hormone secretion; positive regulation of growth hormone secretion; positive regulation of cell population proliferation; positive regulation of multicellular organism growth; cellular response to insulin stimulus; somatotropin secreting cell development; regulation of protein metabolic process; lactation; regulation of intracellular steroid hormone receptor signaling pathway; hormone metabolic process; positive regulation of hormone secretion; cAMP-mediated signaling; cellular response to glucose stimulus; signal transduction; multicellular organismal reproductive process; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2692
	14602
	ENSG00000106128
	ENSMUSG00000004654
	Q02643
	P32082
	NM_000823; NM_001009824
	NM_001003685
	NP_000814
	NP_001003685
	Wikidata
View/Edit Human	View/Edit Mouse

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase. GHRHR is distinct from the growth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone releasing peptides act to release growth hormone.

Function

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.

Ligands

Agonists

Antagonists

MZ-5-156