Folate receptor
| Folate receptor family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Folate_rec | ||||||||
| Pfam | PF03024 | ||||||||
| InterPro | IPR004269 | ||||||||
| |||||||||
Folate receptors bind folate and reduced folic acid derivatives and mediates delivery of tetrahydrofolate to the interior of cells. It is then converted from monoglutamate to polyglutamate forms - such as 5-methyltetrahydrofolate - as only monoglutamate forms can be transported across cell membranes. Polyglutamate forms are biologically active enzymatic cofactors required for many folate-dependent processes such as folate-dependent one-carbon metabolism. These proteins are attached to the membrane by a GPI anchor. A riboflavin-binding protein required for the transport of riboflavin to the developing oocyte in chicken also belong to this family.
Human proteins from this family include:
- FOLR1: folate receptor 1 (adult),
- FOLR2: folate receptor 2 (fetal), and
- FOLR3: folate receptor gamma.